Medical Science Liaison and Medical Affairs consultant with over a decade of experience leading Phase I–IV clinical research initiatives across oncology, immunology, rare diseases, and other therapeutic areas. Trained as a scientist, clinician/investigator, and educator, he brings a unique perspective to medical affairs, connecting cutting-edge science with practical clinical applications to optimize patient outcomes. He excels at understanding complex disease states, evaluating treatment options, and staying ahead of emerging trends in healthcare.
Throughout his career, he has revitalized patient care protocols, influenced clinical practices, and secured NIH funding for innovative projects. He is experienced in managing clinical trials from conception to completion, ensuring adherence to timelines, budgets, and regulatory requirements, while analyzing market access and adoption strategies within dynamic healthcare landscapes.
Adept at identifying and cultivating relationships with Key Opinion Leaders (KOLs) and cross-functional stakeholders, he thrives on collaboration to drive meaningful impact in patient care and medical strategy. Passionate about translating scientific knowledge into actionable insights, he combines critical thinking, emotional intelligence, and project management expertise to support both research innovation and clinical excellence.
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Led 3 successful patient recruitment initiatives for pharmaceutical-sponsored Phase 3 clinical trials, achieving results in under 3 months.
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Designed and implemented a risk-stratification model for late antibody-mediated rejection in ABO-incompatible kidney transplant recipients, enabling tailored longitudinal patient monitoring.
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Evaluated complement-inhibition strategies in patients with complement-activating anti-HLA antibodies, demonstrating a significant reduction in 3-month rejection incidence and advancing precision therapy in transplant immunology.
- Written and awarded 5 NIH grants – Stevens
- Dean’s Scholarship – Stevens
- Presidential Scholarship – NYU
- Shi, Yelu & Michael, Matthew A & Zhang, Yong. (2021).
HNO to NO Conversion Mechanism with Copper Zinc Superoxide Dismutase, Comparison with Heme Protein Mediated Conversions, and the Origin of Questionable Reversibility.
Chemistry, 27(15), 5019-5027.
10.1002/chem.202100015 - Talay, Robert S & Liu, Yaling & Michael, Matthew & Li, Anna & Friesner, Isabel D & Zeng, Fei & Sun, Guanghao & Chen, Zhe Sage & Zhang, Qiaosheng & Wang, Jing. (2021).
Pharmacological restoration of anti-nociceptive functions in the prefrontal cortex relieves chronic pain.
Progress in Neurobiology, 201, 102001.
10.1016/j.pneurobio.2021.102001 - Bhagi-Damodaran, Ambika & Michael, Matthew A & Zhu, Qianhong & Reed, Julian & Sandoval, Braddock A & Mirts, Evan N & Chakraborty, Saumen & Moënne-Loccoz, Pierre & Zhang, Yong & Lu, Yi. (2017).
Why copper is preferred over iron for oxygen activation and reduction in haem-copper oxidases.
Nature Chemistry, 9(3), 257-263.
10.1038/nchem.2643 - Rorick, Amber & Michael, Matthew A & Yang, Liu & Zhang, Yong. (2015).
Toward Relatively General and Accurate Quantum Chemical Predictions of Solid-State (17)O NMR Chemical Shifts in Various Biologically Relevant Oxygen-Containing Compounds.
Journal of Physical Chemistry B, 119(35), 11618-11625.
10.1021/acs.jpcb.5b06536 - Michael, Matthew A & Pizzella, Gianna & Yang, Liu & Shi, Yelu & Evangelou, Tiffany & Burke, Daniel T & Zhang, Yong. (2014).
HNO/NO Conversion Mechanisms of Cu-Based HNO Probes with Implications for Cu,Zn-SOD.
Journal of Physical Chemistry Letters, 5(6), 1022-1026.
10.1021/jz5002902